The Commodores beat the 100-degree heat index, and the Pirates, on Saturday.
Vanderbilt warmed up in the Saturday sun, looking to secure its fifth College World Series appearance.
VandyBoys fans got ready for Saturday on Jess Neely Drive during Fan Fest.
Vanderbilt finished the 2021 campaign with a 29-6 record at home while outscoring its opponents 241-101.
The Commodores are 10-1 in their last 11 postseason games at Hawkins Field.
Jack Leiter went 7.0 innings, allowing just two hits and one run while striking out 10 and walking only three.
Through four frames, Leiter fanned eight.
The two teams combined for three hits, all singles, two walks and 11 whiffs through the first four innings.
Tied 0-0 through four, the Commodores took a 2-0 lead in the top of the fifth after taking advantage of a pair of walks.
Javier Vaz and Jayson Gonzalez drew consecutive walks with one out. A double steal on strike three to Enrique Bradfield Jr. put runners on second and third with two outs, setting the table for Carter Young's two-run single to right center.
East Carolina hit a solo home run to open the bottom of the seventh, but a double play ended the inning with the Commodores up 2-1.
Vanderbilt added two runs in the top of the ninth for the 4-1 final.
A two-out, bases-loaded walk to Dominic Keegan forced in Gonzalez with the Commodores' fourth run of the game.
Nick Maldonado came in for the eighth and ninth and retired all six Pirates in order.
Maldonado clinched the Nashville Super Regional with one final strikeout that set off a wild celebration at Hawkins Field.
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